Undesirable effects of opioid therapy
Patients, who go through the initial stage of the pharmaceutical pain treatment with Tramadol, maydevelop vomiting, headache, dry mouth, nausea, tremors, or dizziness. Since the majority of common side effects of this pain reliever are dose-depended, patients can reduce the risk of its adverse reactions by complying with the recommended dosing schedule.
Abrupt discontinuation of opioid therapy increases the likelihood of withdrawal symptoms, which can manifest through tachycardia, palpitations, sweating, fever, anxiety, insomnia. By decreasing Tramadol dose systematically, you can reduce the risk of these withdrawal symptoms.
Tramadol has a potential for drug-drug interaction with CNSsuppressing agents. With such interaction, the probability of respiratory depression or sedation increases significantly.
To lower the risk of these undesirable effects, patients are recommended to use the lowest possible doses of Tramadol, when using other pain relievers, antihistamines, tranquilizers (in particular benzodiazepines).
Blood concentration of Tramadol can be increased by alcohol. Thus, patients on Tramadol are not recommended to consume alcoholic drinks.
Therapy with MAO inhibitorsis a contraindication to Tramadol use. This pain medication should not be taken14 days before or after a pharmaceutical treatment course with such medicines, as Eldepryl, Parnate, Marplan or Nardil.